Online supplement Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages
نویسندگان
چکیده
Richard N van Zyl-Smit, Anke Binder, Richard Meldau, Patricia L Semple, Alicia Evans, Peter Smith, Eric D Bateman, Keertan Dheda Lung Infection and Immunity Unit, Division of Pulmonology & UCT Lung Institute, Department of Medicine, University of Cape Town, South Africa. Division of Pharmacology, Department of Medicine, University of Cape Town, South Africa. Department of Infection, University College London Medical School, United Kingdom. Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
منابع مشابه
Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages.
BACKGROUND There is a strong epidemiological link between smoking and tuberculosis (TB), but the association is confounded by socioeconomic and other factors. A direct relationship between cigarette smoke and poor treatment-related outcomes in patients with TB is therefore questionable. We investigated whether constituents of tobacco smoke impair mycobacterial host immune responses in vitro. ...
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Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), a chronic inflammatory disease of the airway. The increased expression of inflammatory proteins results from enhanced gene transcription, as these mediators are induced in a cell-specific manner. Changes in transcription depend on chromatin remodeling and the relative activities of histone acetyl-transferases (H...
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